When it comes to profound depression, many people just can't get relief from current treatments.
Now there's more evidence that the anesthetic ketamine, sometimes abused as a club drug, has potential as a fast-acting treatment for the condition.
Doctors at the Mayo Clinic gave 10 patients ketamine twice a week as an infusion that lasted 100 minutes. All the people had depression that had resisted other treatments. The patients got ketamine until their symptoms abated or they'd had four infusions of the drug.
The two Koreas have agreed in principle to talks aimed at mending their almost nonexistent relations, but they are stalled on the question of where to meet.
South Korea has suggested that high-level talks take place in its capital, Seoul, but North Korea has countered that only lower-level negotiations should take place and they should be held in its border city of Kaesong.
The rival Koreas have not met face to face for such negotiations since February 2011.
It is as embarrassing a diplomatic gaffe as you can make: French President François Hollande was in the same room as Japanese Prime Minister Shinzo Abe, this morning, when he offered the "Chinese people" condolences for the 10 citizens it lost during the Algerian hostage crisis in January.